(I do believe this is the latest I’ve updated! It’s crazy with Christmas coming up and life in general.-cottontop)

Human infections with novel influenza A viruses normally found in swine are rare events. Recently, however, the frequency of such detections has increased. This could be occurring for a number of reasons, including one or more of the following factors: First, laboratory methods for testing for these viruses in the United States were improved following the 2009 H1N1 pandemic. These improvements may be resulting in viruses being identified now that would have gone undetected previously. Second, this could be due to increased surveillance in the United States for influenza at this time of year. CDC has requested that states analyze, and then send, their first influenza virus specimens of the season for seasonal influenza surveillance purposes. This practice, coupled with very low levels of seasonal flu activity at this time, could mean that sporadic novel influenza infections are more likely to be tested. Third, it is possible that the increased frequency of detection of novel influenza viruses with swine origins identified by CDC represents a true increase in the number of such cases, possibly occurring from exposure to infected swine or through subsequent, limited human-to-human transmission.

The above comments from today’s CDC “Have You Heard” on the two novel human cases, trH1N2 (A/Minnesota/19/2011) and trH3N2 (A/West Virginia/06/2011) list possibilities for the increased detection of novel H1 and H3 triple reassortants, which ignores the sequence similarities between these isolates with the prior 2011 cases, H3N2pdm11. Other than the H1, all other gene segments in the H1N2 case are closely related to the 2010 human trH3N2 cases or the 2011 H3N2pdm11 cases. Similarly, the trH3N2 case matches the prior 2011 cases in all genes except the H2, which is closely related to swine H3N2 sequences.

Thus, the close relationship between these human cases and the prior cases indicates several different triple reassortants are circulating in humans, and the abysmal surveillance described above, which target one case per state, limits the true picture of the frequencies, which appear to be alarmingly high in US children under the age of 10. Continued:


• Rises to 22 the number of confirmed cases of swine flu in Ceará

• CIDRAP News: Hong Kong residents, poultry workers see low avian flu risk
• China confirms bird flu outbreak in Tibet
• China Reports Bird Flu in Tibet, Animal-Health Organization Says

• City gets high-tech research lab for testing of airborne diseases

• Bird Flu Keeps Threatening Indonesia
• RI Opens First WHO Airborne Infection Isolation Rooms
• Indonesia Receives Facilities from WHO to Contain Bird Flu

• Poultry deaths spur bird flu fear

• Bird flu threat looms large over Pakistan

United States
• CIDRAP News: CDC reports two more novel flu cases
• KY: Health department confirms 14 flu cases in Lexington
• MN: Baby’s flu case was mild, but strange enough to raise flags

• Health department warns of new ‘swine flu’ virus strain (Link)

• Recombinomics: PB1 E618D In Novel trH1N2 Minnesota Case Raises Concerns
• Recombinomics: Human Transmission of Multiple Novel Influenza Constellations
• Recombinomics: CDC Discovers 2011 H3N2pdm11 Pandemic By Accident
• Recombinomics: CDC Urban Legend: H3N2pdm11 Not In Big Cities
• Recombinomics: CDC Upates Comments On H3N2pdm11 In Swine

• Bird flu virus now deadly to humans
• Get your shot! Swine flu may cause baldness