Based on available data, among Japanese oseltamivir resistant viruses, the vast majority were from cases treated or prophylaxed with oseltamivir.
The recently released H1N1 sequences from Japan clearly demonstrate the spread of oseltamivir resistance (H274Y) via clonal expansion. 10 of the 13 sequences with H274Y were closely related and mapped to a branch that had no isolates without H274Y. Moreover one additional sequence, A/Kagawa/2/2011, was closely related and was on an adjacent branch with one isolate, A/Shiga/35/2011, that did not have H274Y. One of the other isolates with H274Y, A/Iwate/1008/2011, was related to other sequences from Japan, while the other H274Y positive sequence, A/Hiroshima/45/2011, was related to US S188T sequences.
Thus, 12 of the 13 sequences were from 2011 (representing 38.7% of the 2011 sequences released by NIID) and the vast majority were spreading via clonal expansion, contracting the above quote in the most recent WHO update on H247Y in pandemic H1N1. Continued:
http://www.recombinomics.com/News/06201101/H1N1_H274Y_Japan_Concerns.html
Argentina
• They deny human influenza outbreak in Argentina in the Copa America days (translated) (Link)
• For the Copa America try to hide the alert for outbreaks of influenza A in Mendoza (translated) (Link)
• Outbreak of Influenza A in Mendoza: There is a nearly 60 dead and infected (translated) (Link)
• The Government admits that there is an outbreak of influenza A in Mendoza (Link)
• Alert flu: health operators put in place in Mendoza outbreak cases (Link)
Australia
• South Australia: More cases of the flu in Whyalla (Link)
• Queensland: Seasonal flu hits Gympie early (Link)
Colombia
• Epidemic strikes Amazon nomads (Link)
Egypt
• Egypt: WHO confirms human H5N1 case (fatal) (Link)
India
• 6 H1N1 deaths, 2 dengue victims so far this year (Link)
South Africa
• Avian flu ruffles ostrich industry (Link)
South Korea
• Mom, two daughters stricken by mysterious lung disease (Link)
Sri Lanka
• Virus flu raging among children (Link)
Thailand
• Thailand’s vaccine plants to start production later this year (Link)
Philippines
• Migratory bird monitoring intensified (Link)
United States
• PA: Geisinger Healthcare Workers Must Get Vaccinated Or Wear A Facemask (Link)
• SLU part of study into possible bird flu vaccine (Link)
General
• 2-seat rule might keep you healthy on your next trip (Link)
• Warning on CSL’s flu vaccine (Link)
Research
• Serology studies could inform pandemic flu plans (Link)
Commentary
• Recombinomics: WHO Comment On H274Y Tamiflu Resistance Raises Concerns (Link)
