In Low California, José Bustamante Moreno, secretary of Health, said that two sick patients have presented himself; one of them died

The above translation describes an H1N1 death in Baja, California.  Like Chihuahua, the dead and severe cases represent a large percentage of detected cases.  Media reports in Mexico are now starting to mention multiple “mutations” which again suggests that the H1N1 has evolved considerably.

The sequences from swine in Costa Rica as well as a large array of reassortants (primarily H1N2) which have swapped genes with pandemic H1N1 raise concerns of additional jumps back to human.  This likelihood is increased because the genes circulating in swine have circulated previously in humans. The Costa Rica swine sequences had pandemic H1 and N1, but there were many changes that would create serotyping issues and would have limited cross reactivity with protective antibodies.

This recent history, coupled with the large number of severe and fatal cases in Mexico, relative to the total number of cases identified raises concerns that an evolved sub-clade has jumped back to humans from swine. The appearance of this sub-clade would be likely to happen at this time of year for the same reasons the 2009 pandemic began in late season.  Competing flu genomes are declining now in the northern hemisphere, creating an environment favorable for the emergence of a new sub-clade.

This level of concern has led to travel checks on those arriving in Mexico City from Chihuahua and Texas.  However, the H1N1 has already spread throughout Mexico, so such checks are unlikely to succeed. (Snip)

http://www.recombinomics.com/News/03311101/H1N1_Mexico_Baja.html

Mexico
•  Mexico on alert after 4 die of swine flu (Link)
•  Cofepris guaranteed supply of vaccines against H1N1 (Link)
•  Increased cases of influenza in Europe, the United States and northern Mexico (Link)

•  Mexico: Strengthen health fence in Mexico City for influenza A H1N1 cases detected in the north of this country (Link)

•  Highlights A H1N1 influenza types (Link)

Bangladesh
•  6,000 hens culled in Manikganj (Link)
•  Bird flu gets strength to endure increased temperature (Link)

•  ProMED: Low Pathogenic Avian Influenza (H9N2), Human – Bangladesh: (Dhaka) (Link)

Canada
•  British Columbia: H1N1 still claiming lives  (Link)

Honduras
•  Health authorities warn of measures to prevent influenza A H1N1 (Link)

Indonesia
•  Pekanbaru Citizen Alert (translated) (Link)

•  Padang Hospital Treats 27 Bird Flu Suspects (translated) (Link)
•  Update The Case Of Bird Flu (Link)
•  WHO confirms fatal H5N1 case (28F Yogyakarta)(Link)

•  Indonesian H5N1 death, cross-species avian flu transmission, pandemic vaccine gap (Link)

Thailand
•  Thai researchers find hybrid of 2009 H1N1 and swine virus in pigs (Link)

United States
•  MO: Ag inspectors looks into (low pathogenic) Avian Influenza case (Link)
•  H7N3 found on Missouri turkey farm (Link) OIE Report (Link)

•  MO: Careful disposal of turkeys with avian flu is all-day process at farm in Polk County (Link)

•  SD: South Dakota flu death toll reaches 17 (Link)

Venezuela
•  Venezuela confirms 482 A/H1N1 influenza cases (Link)
•  489 cases H1N1 virus in Venezuela and laboratory saturated with samples (translated) (Link)
•  Confirmed two new cases of H1N1 in Zulia (Link)
•  Venezuela Confirms 586 Swine-Flu Cases – Health Minister (Link)
•  Most cases of H1N1 in Venezuela are women (Link)

•  586 confirmed cases of influenza A H1N1 in Venezuela (Link)
•  Reach 586 cases of influenza A (H1N1) in Venezuela (Link)

Zambia
•  Swine flu hits Ndola school (Link)

Research
•  US awards contract for long-acting flu antiviral (Link)
•  Swine outbreak of pH1N1 supports human to swine transmission (Link)

•  Study: Cross-species avian flu transmission varies with subtype (Link) PLoS One report: (Link)

Commentary
•  Recombinomics: Mexico City Starts Chihuahua and Texas H1N1 Traveler Checks (Link)
•  Recombinomics: S188T Low Reactors In European H1N1 (Link)

•  Recombinomics: Rapid H1N1 Evolution In Mexico Raises Pandemic Concerns (Link)
•  Recombinomics: H1N1 Death Cluster Grows In Juarez MexicoTraffic Department (Link)

•  Recombinomics: Fatal and Severe H1N1 Cases In Mexico Increase (Link)
•  Recombinomics: H1N1 Spreads to El Salvador (Link)

 

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