German H1N1Tamiflu Resistance Cluster Raises Concerns
Recombinomics Commentary 17:34
December 20, 2009

For the first time in Germany when swine flu patients – a ten year old and a 31-year-old man – resistance to the influenza drug Tamiflu has been demonstrated.

Both had come with pre-existing conditions and a “weak defense” to the University Hospital of Munster, said the clinic on Friday. They were already infected with swine flu in the reception.

The above translation describes the first to H274Y confirmed cases in Germany.  Although Germany has a strong surveillance system and has reported H1N1 since the spring, the first reported cases of H274Y come at a time when reported cases are exploding in the United States, Japan, and the Netherlands, suggesting H274Y is transmitting. This is further supported by the presence of H274Y in two patients from the same hospital.  Hospital outbreaks have been reported in Wales and North Carolina in immuno-compromised patients and in North Carolina, three of the four died.


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•  WHO reports H1N1 symptoms caused 10,000+ swine flu deaths worldwide, CDC says 10,000+ in U.S. alone (Link)
•  Positive interim results from Medicago’s H5N1 vaccine Phase I human clinical trial (Link)
•  Sanofi-Aventis agrees to buy US health-care company Chattem for $1.9 billion (Link)
•  One Dose of H1N1 Vaccine Enough for Young (Link)
•  The upside of a pandemic: Experts say lots learned from H1N1 experience (Link)
•  Germs have many names, but the remedies stay the same (Link)
•  Israel Orders 150 Doses of H1N1 Antiviral Peramivir (Link)

•  Crofsblogs: Cuba – 41 deaths (Link)
•  Crofsblogs: H5N1 cases in Vietnam on apparent increase (Link)