D225G and D225N In Utah Patient Raises Pandemic Concerns Recombinomics Commentary 23:55 December 6, 2009 The CDC has put HA sequences, A/Utah/42/2009, from a Utah patient (28F) on deposit at Genbank, which has D225G and D225N. Moreover, the sequence from the original sample gives mixed signals at tandem positions, revealing significant heterogeneity that the codon. A clone for the original sample has D225G. D225N and D225G have been identified in necropsy lung samples from Brazil (A Sao Paulo/53845/2009 and A/Sao Paulo/53838/2009 have D225N while A/Sao Paulo/53225/2009 and A/Sao Paulo/53206/2009 have D225G) raising concerns that these polymorphisms are associated with more severe disease.

The severity may be linked to viral load, because D225G and D225N were present as mixtures in early cases in the US in California and Texas. In fact the vaccine target, A/California/7/2009 was a mixture for D225G, as were several other isolates isolated at about the same time in Texas and California. Other isolates in the same areas, as well as New York, did not give mixed signals, but D225G was found in milder cases.

full article

http://www.recombinomics.com/News/12060901/D225G_D225N_Utah.html

China
•  Local authorities ‘could be underreporting’ (Link)

Egypt
•  Death 30 and 31 from swine flu (translated) (Link)

Greece
•  confirmation of 32 deaths in new totals, 3 more critical (Link)

India
•  Nine more swine flu deaths (Link)
•  Five swine flu deaths in Delhi, India toll 632 (Link)
•  4 more H1N1 deaths in New Delhi, a 5th not counted (Link)
•  Himachal Pradesh confirms 3rd H1N1 death (Link)
•  3 more deaths confirmed in Punjab, total either 6 or 8 now (Link)
•  Five swine flu deaths in Delhi, India toll 632 (Link)
• Jaipur counts 4 more deaths, total in Rajasthan state now 77  (Link)

Japan
•  70% set to hoard in swine flu crisis (Link)

Palestine
•  Gaza: First swine flu death (Link)

Saudi Arabia
•  10 more H1N1 deaths (Link)

United States
•  US: At death’s door with H1N1 for three weeks (Link)
•  FL:Two More H1N1 Deaths In Miami-Dade  (Link)
•  IL: Minorities hit harder by H1N1 (Link)
•  IN: Vanderburgh County Opens H1N1 Clinics to General Public (Link)
•  MA: Massachusetts confirms 7 more deaths in past 2 weeks, total now 24 (Link)
•  PA: Washington Co-4th county death (Link)
•  PA: (1) New Death on PA DOH Website (Link)
•  TN: Flu vaccines available in Rutherford County (Link)
•  TX: Dallas announced last week, started this morning (Link)
•  WA: Swine flu vaccine open to everyone in Island County (Link)

General
•  ‘Rational drug design’ identifies fragments of FDA-approved drugs relevant to emerging viruses (Link)
•  Patient in Utah has swine flu virus with D225G, low reactor H1N1 mutation causing lung hemorrhaging (Link)
•  Don’t let swine flu crash your holiday party (Link)

Research
•  Successful Phase I/II Clinical Trial for BiondVax (Link)
•  Ancient HIV stowaway may hold clue to transmission  (Link)

Commentary
•  Experts say flu pandemic could be mildest on record (Link)

Advertisements