H1N1 RBD Changes at 225 Create Vaccine Mismatch Concerns
Recombinomics Commentary 14:22
November 29, 2009

Originating Laboratory provider of clinical specimen(s)
and/or virus isolate(s)
 [Ukraine, Kiev] Ministry of Health of Ukraine
 
Address:
Central Sanitary Epidemiological Station 41 Yaroslavskaya str. 04071 Kiev Ukraine
 
Sample ID given by the sample provider
 
Submitting Laboratory generator of data
 [UK, London] WHO Collaborating Centre
 
Address:
 The National Institute for Medical Research (NIMR) The Ridgeway – Mill Hill London NW7 1AA, UK
 
Sample ID given by the sequencing lab:
 
Antigenic characterisation:
 A/California/7/2009 like. Low reactor
 
The above characterization of A/Lviv/N6/2009, which was placed on deposit at GISAID by Mill Hill, raises concerns about the evasion of pandemic H1N1 sequences which change position 225.  The above isolate has only one amino acid change in HA, D225G, which strongly implicates D225G in the low reactor results.  A low reactor reduces the titer by four fold or more, which signals a mismatch. Mismatched vaccine create the potential for the section of the variant, which could create problems since D225G was found in four of four fatal cases in Ukraine, and several countries (Brazil, Ukraine, Norway, France, China) found D225G in fatal and or severe cases.

full article

http://www.recombinomics.com/News/11290901/RBD_225_Mis.html

 

Australia
•  Daughter’s legs amputated, dad dying of cancer, housing needed (Link)

Azerbaijan
•  Situation in connection with “Bird flu” is stable (Link)

Canada
•  British Columbia: WHO monitors for H1N1 at ’12 games (Link)
•  Second wave of H1N1 pandemic may have peaked: health officials (Link)

China
•  China urges intensified supervision on A/H1N1 flu in animals (Link)

Egypt
•  Egypt announces death No. 21 swine flu of a young man from Helwan (translated) (Link)

France
•  France struggles to cope with surge in flu vaccine demand (Link)

Greece
•  Number of people who have died from H1N1 virus rises to 16 (Link)

Iran
•  ‘No Iranian pilgrim has contracted swine flu’ (Link)

Japan
•  Japan experts go to Canada to study flu vaccine reactions (Link)

Qatar
•  Health centres see huge rush for H1N1 jabs  (Link)

Saudi Arabia
•  Confirmation of 5th H1N1 victim at Haj (Link)
•  Haj winds up without mass swine flu outbreak  (Link)

Slovenia
•  Third Swine Flu Death in Slovenia (Link)
•  Another Person Dies of Swine Flu (Link)

Tunisia
•  President Zein al-Abedin Bin Ali ‘caught’ the H1N1 (Link)

United States
•  Vaccines slowly go high-tech (Link and link)
•  TX: Local official calls for wider vaccination against A/H1N1 flu (Link)

General
•  H1N1 D225G mutation a reason of concern – Part 1 (Link)
•  H1N1 D225G mutation a reason of concern – Part 2 (Link)
•  More than 1,000 deaths in past week from H1N1: WHO (Link)
•  Swine flu mutations spreading in Europe – WHO (Link)
•  Flu shot remains dilemma for many (Link)
•  Planning for a Pandemic – Can History Inform Action (Link) (Link)

Commentary
•  Recombinomics: WHO Confirms D225G Vaccine Failure (Link)
•  H1N1 outbreak helping us learn about immunity (Link)
•  H1N1 vaccine: It’s hard to prioritize in person (Link)
•  Effect Measure: Pics of the flu virus and some its components (Link)

 

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